Rescue and characterization of the first West African arburg virus 2021 from Guinea

نویسندگان

چکیده

Marburg virus (MARV) is a causative agent of severe hemorrhagic fever with high fatality rates endemic in central Africa. Current outbreaks MARV Equatorial Guinea and Tanzania underline the relevance as public health emergency pathogen. In 2021, first known human case was confirmed Guinea, West Since no infectious could be isolated from that fatal we generated recombinant (rec) by reverse genetics order to study characterize this new MARV, which occurred Africa for time, terms its growth properties, detection antibodies, therapeutic potential compared strains. Our results showed solid viral replication recMARV human, bat, monkey cell lines comparison other We further demonstrated cells can inhibited nucleoside analogue remdesivir. Taken together, successfully reconstitute de novo African showing similar kinetics approach has proven successful characterizing emerging viruses, especially when isolates are missing genome sequences incomplete.

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ژورنال

عنوان ژورنال: Heliyon

سال: 2023

ISSN: ['2405-8440']

DOI: https://doi.org/10.1016/j.heliyon.2023.e19613